PhD - fellow at Oslo universitetssykehus

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PhD - fellow

Institute for Experimental Medical Research, HLK, Oslo University Hospital HF

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About the Stilling

PhD Stilling Investigating Mechanobiology in the Heart

Applications are invited for a 3-year PhD Stilling investigating how cardiac muscle cells (cardiomyocytes) sense mechanical signals, and how these pathways control the cell's structure and function. Based on these insights, the project will seek to understand how mechanical overload in diseases such as heart failure can be therapeutically targeted. The Stilling will be based at the Institute for Experimental Medical Research (IEMR) located at Oslo University Hospital.

IEMR is an innovative and dynamic medical research environment that conducts research focused on understanding the basic mechanisms of cardiac (patho)physiology. With approximately 60 employees and six research groups, our expertise spans molecular biology, physiology and cardiology. The project will be supervised by Professor William Louch.

Oslo University Hospital is a workplace with great diversity. We believe this is essential to perform the tasks required of us. Therefore, we pursue diversity among our job applicants and encourage everyone to apply regardless of who you are.

Key information

Application deadline:

Employer:

Oslo universitetssykehus HF

Town/city:

Oslo

Title:

PhD

Stillings:

1

Full-time/part-time:

Full-time

Employment type:

Contract

Percentage of full-time:

100

Webcruiter ID:

Start date:

End date:

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Work tasks

The PhD Stilling will be 3 years in duration and, depending on starting date, have latest completion of the end of 2029. Funding will be provided by a grant from the South-Eastern Norge Regional Health Authority.

The heart is highly mechanosensitive, allowing it to "remodel" when its workload changes. The Louch group has shown that workload is critically sensed by cardiomyocytes. With a moderate increase in workload, such as during exercise, compensatory cardiomyocyte remodeling occurs and cardiac function improves. However, there is a "tipping point", beyond which high workload triggers pathological remodeling, leading to impaired cardiac performance and heart failure. It is unknown how such changes are triggered, and how these signals can be therapeutically targeted.

The current project aims to address these issues using living myocardial slices; a system which allows the culture of human tissue to investigate the tissue response to predefined workloads. It is hypothesized that the tipping point represents a switch, where a novel set of sensory proteins are activated to trigger pathological remodeling. Using these data, the project will identify and test the efficacy of novel mechanosensitive targets, using tissue from heart failure patients. Thus, the project will provide proof-of-principle for a new class of therapies aimed at treating heart failure by directly targeting the mechanical signals underlying this disease.

Qualifications

We ask all applicants to respond to the qualification requirements. We will not consider applications lacking this information.

• We are looking for talented and highly motivated candidates of all nationalities who have a keen interest in cellular and cardiovascular research
• Applicants must hold a BSc in Biology, Biomedical Sciences, Engineering, or Physics
• Previous experience with:
• Advanced light microscopy techniques including confocal imaging
• Qualitative and quantitative analysis of microscopy images, using tools such as ImageJ
• Experimental testing of genetic alterations
• Fluent oral and written communication skills in English are required

Value will be placed on compatibility of the applicant's professional and personal disStilling, with

strengths in:

• Systematic approach
• Analysis and assessment
• Implementation
• Self development
• Initiative and accountability

Personal qualifications

• Enthusiastic, reliable and structured
• Genuine interest in research
• Dedicated and responsible

We offer

• Salary according to agreement
• A stimulating, challenging and friendly international working environment with broad expertise
• Technical assistance and training
• Attractive welfare benefits and a generous pension agreement, in addition to Oslo's family-friendly environment with its rich opportunities for culture and outdoor activities
• We take care of our new employees and support you through the start-up phase with our central new employee program, read more:
• We have welfare offers for our employees, e.g. theater tickets, Selskap choirs, Selskap sport teams etc.

At Oslo University Hospital we provide advanced patient care, research, experimental treatment, teaching and inovation at a high international level. We are therefore the rearguard of all Norge. We need you on the team.

Does this sound like a Stilling for you? We look forward to reading your application.

Do you want to know more Om oss?
Read about or work place here:
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How to apply:

• Cover letter (statement of motivation, summarizing scientific work and research interest)
• CV (summarizing education, Stillings, pedagogical experience, administrative experience and other qualifying activities)
• Copies of educational certificates (academic transcripts only)
• List of reference persons: 2-3 references (name, relation to candidate, e-mail and phone number)

The application with attachments must be delivered in our electronic recruiting system Webcruiter. The attachments should be in the form of one or two pdf files that include all requested items.

Foreign applicants are advised to attach an explanation of their University's grading system. Please note that all documents should be in English (or a Scandinavian language).

In assessing the applications, special emphasis will be placed on the documented, academic qualifications in regards to the project description, and the candidate's motivation and personal suitability. Interviews with the best-qualified candidates will be arranged.

It is expected that the successful candidate will be able to complete the project in the course of the period of employment.

Address:

Kirkeveien 166, 0450 Oslo, Norge

Open directions

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Contacts

William Louch

Professor

Email:

About the employer

Developing tomorrow's treatment - together with the patient.
Oslo University Hospital with employees is a learning and forward-thinking organization. We have a leading role in the development of research and innovation, as well as the development of tomorrow's healthcare, precision medicine and treatment. Here you will find some of Norge's leading experts in their fields, and be part of the largest health care workplace in the Land. Our work environment is characterized by openness and respect. Regardless of educational background or experience, you will have the opportunity to develop and use your expertise in a place where it really matters.

Jobbinformasjon:

• Selskap: Oslo universitetssykehus
• Stilling: PhD - fellow
• Arbeidssted: Oslo
• Land: NO

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